Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study
Identifieur interne : 000867 ( Main/Exploration ); précédent : 000866; suivant : 000868Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study
Auteurs : K F Pedersen [Norvège] ; G. Alves [Norvège] ; D. Aarsland [Norvège] ; J P Larsen [Norvège]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2009-11.
Abstract
Background: Apathy is a common but under-recognised behavioural disorder associated with depression and cognitive impairment in patients with Parkinson disease (PD). However, the longitudinal course of apathy in PD has not been studied. Objective: To examine the occurrence of and risk factors for apathy over time in a representative sample of patients with PD. Methods: A sample of 139 patients was drawn from a population-based prevalence study of PD in Rogaland County, Western Norway. Apathy was measured with the Neuropsychiatric Inventory, using a composite score ⩾4 to indicate clinically significant apathy. Additional measurements included standardised rating scales for parkinsonism, depression and cognitive impairment. A follow-up evaluation was carried out in 79 patients (78.2% of the survivors) 4 years later. Results: Of the 79 patients included in this study, 29 patients (36.7%) had never had apathy, 11 (13.9%) had persistent apathy, and a further 39 (49.4%) developed apathy during follow-up. At follow-up, patients with apathy were more frequently depressed and demented than never-apathetic patients. Dementia at baseline and a more rapid decline in speech and axial impairment during follow-up were independent risk factors for incident apathy. Conclusions: Apathy is a persistent behavioural feature in PD with a high incidence and prevalence over time. Progression of motor signs predominantly mediated by non-dopaminergic systems may be a useful preclinical marker for incident apathy in PD.
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DOI: 10.1136/jnnp.2008.170043
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Aarsland</name></author><author><name sortKey="Larsen, J P" sort="Larsen, J P" uniqKey="Larsen J" first="J P" last="Larsen">J P Larsen</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2A67AF1CC06C18EEAE62EEA6ED79B6A0CA40DE24</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1136/jnnp.2008.170043</idno><idno type="url">https://api.istex.fr/document/2A67AF1CC06C18EEAE62EEA6ED79B6A0CA40DE24/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001F80</idno><idno type="wicri:Area/Main/Curation">001C84</idno><idno type="wicri:Area/Main/Exploration">000867</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study</title><author><name sortKey="Pedersen, K F" sort="Pedersen, K F" uniqKey="Pedersen K" first="K F" last="Pedersen">K F Pedersen</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Alves, G" sort="Alves, G" uniqKey="Alves G" first="G" last="Alves">G. 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Aarsland</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Psychiatry, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, University of Bergen, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Larsen, J P" sort="Larsen, J P" uniqKey="Larsen J" first="J P" last="Larsen">J P Larsen</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Neurology, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Clinical Medicine, University of Bergen, Bergen</wicri:regionArea><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2009-11">2009-11</date><biblScope unit="volume">80</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1279">1279</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">2A67AF1CC06C18EEAE62EEA6ED79B6A0CA40DE24</idno><idno type="DOI">10.1136/jnnp.2008.170043</idno><idno type="href">jnnp-80-1279.pdf</idno><idno type="ArticleID">jn170043</idno><idno type="PMID">19864662</idno><idno type="local">jnnp;80/11/1279</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background: Apathy is a common but under-recognised behavioural disorder associated with depression and cognitive impairment in patients with Parkinson disease (PD). However, the longitudinal course of apathy in PD has not been studied. Objective: To examine the occurrence of and risk factors for apathy over time in a representative sample of patients with PD. Methods: A sample of 139 patients was drawn from a population-based prevalence study of PD in Rogaland County, Western Norway. Apathy was measured with the Neuropsychiatric Inventory, using a composite score ⩾4 to indicate clinically significant apathy. Additional measurements included standardised rating scales for parkinsonism, depression and cognitive impairment. A follow-up evaluation was carried out in 79 patients (78.2% of the survivors) 4 years later. Results: Of the 79 patients included in this study, 29 patients (36.7%) had never had apathy, 11 (13.9%) had persistent apathy, and a further 39 (49.4%) developed apathy during follow-up. At follow-up, patients with apathy were more frequently depressed and demented than never-apathetic patients. Dementia at baseline and a more rapid decline in speech and axial impairment during follow-up were independent risk factors for incident apathy. Conclusions: Apathy is a persistent behavioural feature in PD with a high incidence and prevalence over time. Progression of motor signs predominantly mediated by non-dopaminergic systems may be a useful preclinical marker for incident apathy in PD.</div></front></TEI><affiliations><list><country><li>Norvège</li></country></list><tree><country name="Norvège"><noRegion><name sortKey="Pedersen, K F" sort="Pedersen, K F" uniqKey="Pedersen K" first="K F" last="Pedersen">K F Pedersen</name></noRegion><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D" last="Aarsland">D. Aarsland</name><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D" last="Aarsland">D. Aarsland</name><name sortKey="Aarsland, D" sort="Aarsland, D" uniqKey="Aarsland D" first="D" last="Aarsland">D. Aarsland</name><name sortKey="Alves, G" sort="Alves, G" uniqKey="Alves G" first="G" last="Alves">G. Alves</name><name sortKey="Alves, G" sort="Alves, G" uniqKey="Alves G" first="G" last="Alves">G. Alves</name><name sortKey="Larsen, J P" sort="Larsen, J P" uniqKey="Larsen J" first="J P" last="Larsen">J P Larsen</name><name sortKey="Larsen, J P" sort="Larsen, J P" uniqKey="Larsen J" first="J P" last="Larsen">J P Larsen</name><name sortKey="Larsen, J P" sort="Larsen, J P" uniqKey="Larsen J" first="J P" last="Larsen">J P Larsen</name><name sortKey="Pedersen, K F" sort="Pedersen, K F" uniqKey="Pedersen K" first="K F" last="Pedersen">K F Pedersen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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